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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease

Fig. 3

The mechanisms underlying the role of SETDB1 in cell fate determination and stem cell. SETDB1 trimethylates H3K9 (H3K9me3) to suppress the expression of DPPA2, OTX2, and UTF1 to regulate primordial germ cells (PGC) formation, and to inhibit CEBPβ and CDKN1α, FBP1 and FBP2 expression to affect the hematopoietic stem and progenitor cells (HSPCs), and to repress LINE1 transcript expression to facilitate stem cell self-renewal

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Epigenetics & Chromatin

ISSN: 1756-8935