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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease

Fig. 2

The upstream regulatory mechanisms of SETDB1. The expression of SETDB1 is regulated by transcription factors TCF4, C-MYC, and SP1/SP3. miR-409-3p, miR-621, and miR-29 directly target the 3′-UTR of Setdb1 and inhibits its expression. ATF7IP and UBE2Es directly interact with and monoubiquitinate SETDB1 to enhance the methyltransferase activity of SETDB1. Mithramycin is an inhibitor of SP1/SP3

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Epigenetics & Chromatin

ISSN: 1756-8935