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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

Fig. 7

Decreased expression of SHH, SUFU genes both in low-folate mouse and human NTDs fetuses. A RT-qPCR was used to detect the mRNA levels of Shh, Sufu genes in brain and spinal tissues of NTDs mice. Data are mean ± s.d. (n = 3). *p < 0.05. B Nanostring assay was used to detect the mRNA level of SHH,SUFU genes in the NTDs fetuses’ brain. C Pearson’s correlation analysis was shown between H3K79me2 expression and SHH, SUFU genes. D Pearson’s correlation analysis was shown between folate level and SHH, SUFU genes. E Pearson’s correlation analysis was displayed between DOT1L expression and SHH, SUFU genes. All above data are mean ± sd. (n = 11), *p < 0.05

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Epigenetics & Chromatin

ISSN: 1756-8935