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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

Fig. 2

Aberrant H3K79me2 expression in low-folate human NTDs fetuses. A Changes of H3K79me2 in brain and spinal tissues of human NTDs fetuses and normal fetuses were detected by western bloting, H3 was used as a loading control. B Box-plot was used to quantify signal intensity of H3K79me2 western blot. (Sample size in Normal and NTDs groups, respectively: n = 8.) C Pearson’s correlation analysis was shown between H3K79me2 protein expression of human sample and their maternal folate level. All above data are mean ± sd. (n = 11), *p < 0.05. D Pearson’s correlation analysis was shown between the transcriptional expressions of DOT1L and H3K79me2 protein levels in human samples

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Epigenetics & Chromatin

ISSN: 1756-8935