Fig. 4

Biological interpretations of the predicted pollutant–TF–disorder associations for three representative pollutants. Mouse phenotype ontologies enriched for the genes proximal to pollutant-induced opened DARs are shown in the left panels. Bars representing individual ontology terms are colored based on their parent categories, which were obtained from the Mouse Genome Informatics database. Volcano plots illustrating the results of the proposed DAR-ChIPEA approach are shown in the right panels. Dots indicate individual TFs and are colored based on cell type classes obtained from ChIP-Atlas. Positive and negative values of log₂ fold enrichment (opened DARs/closed DARs; X-axis) indicate TFs enriched in relaxed and condensed chromatin induced by pollutant exposure, respectively. The enrichment score (–log₁₀Q value; Y-axis) indicates the statistical significance of ChIPEA