Fig. 4

Altered cfDNA fragmentation patterns in hypomethylated regions in patients with breast cancer. A–C Distribution of cfDNA fragment size was shown for healthy individuals H1, H2, and H3 in hypermethylated genomic regions (red) and hypomethylated genomic regions (green). D–F Distribution of cfDNA fragment size was shown for patients with breast cancer P1, P2, and P3 in hypermethylated genomic regions (red) and hypomethylated genomic regions (green). The vertical dashed line indicated cfDNA fragment size at 100 bp and 150 bp