Fig. 3

Dynamics of METTL14, RBM15, ALKBH5 during cardiomyocyte differentiation. A Dispersion score of expression levels of m6A writers and erasers during cardiomyocyte differentiation. B Changes in expression levels (blue line) and m6A modification levels (red line) of METTL14, RBM15, ALKBH5 during differentiation. The relative signal represents the change in the latter stage compared to the previous stage. C Distribution of the correlation between the m6A level of the transcriptome and the expression of METTL14, RBM15, and ALKBH5. PCC: Pearson correlation coefficient. D Identification of potential target genes of METTL14, RBM15, ALKBH5. m6A pos/neg cor gene: genes whose m6A levels are positively/negatively correlated with the expression of m6A-related proteins. Expression pos/neg cor gene: genes whose expression levels are positively/negatively correlated with the expression of m6A-related proteins. The p-value was calculated using one-tailed hypergeometric test. (E) GO enrichment analysis of potential target genes of METTL14, RBM15 and ALKBH5