Fig. 2

Dynamics of m6A during cardiomyocyte differentiation. A Heatmap of m6A level for each peak at four differentiation stages, clustered using k-means. B The percentages of m6A with changes (Fold Change > 1.2, red bar) and without changes (blue bar). Right: The peaks that show changes in m6A modification levels on the left are further subdivided into peaks that change once, twice and thrice. C Origin of m6A peaks at various stages during cardiomyocyte differentiation. D The genes related to stem cell maintenance obtained from the GO database were compared with the genes that showed m6A modifications. The p-value was calculated using a one-tailed hypergeometric test. (E) GO enrichment analysis results for the gene sets contained in cluster 8 in A. F Genome browser view of the m6A signal at four differentiation stages on RYR2 and MED21