Table 1 Enrichment of neural genes in hyper- and hypomethylated genes for solid cancers
From: Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
Cancer type | Abbreviation | Number of hypermethylated genes | Percentage of neural gene | FDR | Number of hypomethylated genes | Percentage of neural gene | FDR |
|---|---|---|---|---|---|---|---|
Bladder cancer | BLCA | 1739 | 37.3 | 2.5E−78 | 6186 | 18.6 | 0.99 |
Breast cancer | BRCA | 3163 | 34.2 | 4.1E−91 | 2390 | 16.2 | 0.02 |
Cholangiocarcinoma | CHOL | 2548 | 31.0 | 9.3E−50 | 1004 | 24.5 | 5.5E−05 |
Colon adenocarcinoma | COAD | 2624 | 38.5 | 4.8E−123 | 3153 | 16.8 | 0.04 |
Esophageal cancer | ESCA | 2321 | 33.2 | 2.6E−62 | 2086 | 16.2 | 0.02 |
Head and neck cancer | HNSC | 2328 | 36.6 | 7.1E−93 | 3504 | 16.7 | 0.02 |
Kidney clear cell carcinoma | KIRC | 1848 | 33.4 | 3.2E−53 | 2205 | 18.5 | 0.99 |
Kidney papillary cell carcinoma | KIRP | 2369 | 25.4 | 1.6E−15 | 1156 | 20.3 | 0.24 |
Liver cancer | LIHC | 1808 | 36.7 | 9.0 E−76 | 4955 | 18.6 | 0.99 |
Lung Adenocarcinoma | LUAD | 1970 | 39.7 | 1.2E−109 | 1714 | 15.1 | 0.01 |
Lung squamous cell carcinoma | LUSC | 2060 | 32.9 | 4.0E−54 | 4443 | 16.9 | 0.02 |
Pancreatic cancer | PAAD | 1758 | 41.7 | 3.6E−118 | 1197 | 19.8 | 0.45 |
Prostate cancer | PRAD | 3357 | 31.4 | 1.7E−65 | 1865 | 16.0 | 0.02 |
Rectal cancer | READ | 1750 | 38.5 | 1.4E−88 | 3970 | 17.3 | 0.09 |
Thyroid cancer | THCA | 207 | 30.4 | 2.0E−05 | 734 | 19.9 | 0.53 |
Endometrioid cancer | UCEC | 2684 | 31.1 | 9.7E−53 | 4978 | 18.9 | 0.70 |