Alterations in the hepatocyte epigenetic landscape in steatosis

Table 1 Functional analysis of the DEG clusters

Cluster ID	DEGs per cluster	DEGs overlapping DCDs	DEGs with proximal DMRs	Enriched functions
1	94	1	41	Mitochondrial dysfunction
2	79	0	32	Extracellular matrix collagen
3	61	3	16	Alcohol metabolism
4	84	1	31	Steatohepatitis associated pathways: PI3K-AKT JAK-STAT MAPK

The first column gives the snapshot of the PPA network of each of the 4 clusters built with the DEGs Additional file 7: Fig. S1–4 contain the figures for each cluster, with the cluster ID). The second column gives the number of participating genes (of the DEGs). The third and fourth columns are the overlapping DEGs with differential chromatin domains (DCDs) and differentially methylated regions (DMRs), respectively. Finally, the fifth column provides a summary of the studied functional categories that the genes in the cluster have been linked to

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