Fig. 2
From: Alterations in the hepatocyte epigenetic landscape in steatosis
Integrative analysis of epigenomics data reveals involved transcription factors in LDC gene regulation. a Distribution of the downregulated and upregulated DNase-1 regions in LDC (over Co) among gene bodies, promoters, and intergenic regions. b Integrative analysis of differential DNase1 peaks from deregulated genes lead to the prediction of involved transcription factors using logistic regression. The top panel shows the absolute normalized coefficients of 15 TFs (absolute regression coefficient > 0.125), which are most predictive for the differential genes. The bottom panel shows the TF effect score (Eq. 2) of the ranked TFs in each of the 4 clusters. A positive TF effect score (blue) signifies stronger regulation of DEGs in the cluster in LDC (over Co) than the TF effect score for DEGs in other clusters. c Violin plot showing the distribution of the lengths of the Differential Chromatin Domain (DCD) regions over all the chromosomes. The DCDs were obtained using SCIDDO from histone ChIP-seq data (p-value <  = 0.05)