Fig. 6

Super-enhancer reprogramming by the local tumor microenvironment. The regulatory region at the locus of PDZK1IP1 does not meet super-enhancer calling criteria in HT29 cells grown as culture. It exists as a typical enhancer, with minimal expression (~ 2 TPM by RNA-seq). When the same cells are grown as a subcutaneous xenograft on the back of an immunocompromised mouse, the super-enhancer is induced with significant increases in H3K27ac deposition at the region and approximately 30–40 × increase in PDZK1IP1 expression. Figure reproduced with permission from Nature Communications. Please refer to the original publication (Zhou et al. [114]) for more details and citation