Fig. 5
From: Etiology of super-enhancer reprogramming and activation in cancer
CTCF boundaries restrain super-enhancers from aberrant oncogene activation. Left, under physiologic conditions, a CTCF insulator separates a super-enhancer from a neighboring oncogene and prevents SE–promoter interactions that would lead to oncogene expression. Right, loss of CTCF binding from methylation results in boundary disruption that permits SE–oncogene interactions that result in activation. Figure reproduced with permission from Nature. Please refer to the original publication (Flavahan et al. [91]) for more details and citation