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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Etiology of super-enhancer reprogramming and activation in cancer

Fig. 4

Recurrent focal amplification of a super-enhancer at the KLF5 locus. Recurrent focal amplification (red) in 15 patients with head and neck squamous cell carcinoma (HNSCC) from TCGA in a non-coding region near KLF5. Beneath, H3K27ac ChIP-seq tracks from the HNSCC cell line, BICR-31, with called super-enhancers annotated by green bars. Note the overlap between amplified regions and SEs near KLF5. Figure reproduced with permission from Nature Genetics. Please refer to the original publication (Zhang et al. [9]) for more details and citation

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