Fig. 3
From: Etiology of super-enhancer reprogramming and activation in cancer
Recurrent non-coding insertions lead to super-enhancer formation and TAL1 expression. Left, H3K27ac ChIP-seq tracks showing a super-enhancer at the locus of TAL1 in Jurkat and MOLT-3 cells, both of T-cell acute lymphoblastic leukemia (T-ALL) origin. This super-enhancer is absent in DND-41 T-cell leukemia cells and fetal thymus cells. Right, non-coding region sequences underlying the TAL1 super-enhancer. Note the recurrent insertions (in red) in Jurkat and MOLT-3 cells, as well as in eight patients with T-ALL, that correlate with formation of the TAL1 super-enhancer. Figure reproduced with permission from Science. Please refer to the original publication (Mansour et al. [8]) for more details and citation