Fig. 2

General overview of the WES datasets. The general features of ten erythroleukemic samples are displayed, showing the variant classification (color-coded as a function of the type of mutation, top left), variant type (single nucleotide polymorphisms (SNP), insertions (INS) and deletions (DEL), top middle), and single nucleotide variant (SNV) class (top right). The bottom panel displays the number of variants per sample (each column represents a unique patient), using the same color code as in the variant classification panel. Note that patient m_13_D is spotted as being an outlier with ~ 30-fold more variants than in the other patients. The dashed red line represents the median number of variants in the cohort. The middle panel shows the variant classification summary in the cohort, using the same mutation-specific color code. Finally, the bottom right panel shows the top 20 mutated genes in the patient cohort (the number of variants/mutations is shown on the horizontal axis), with the percentage of patients bearing a mutation in a given gene indicated