Table 1 Inhibitors of histone PTMs
Inhibitor | Target | Concentration/time (24Â h) | Supplier | Catalog reference |
|---|---|---|---|---|
VRK-IN-1 | VRK1 | 600Â nM | MedChem | HY-126542 |
C646 | P300/CBP/PCAF | 5 μM | Selleck | S7152 |
Vorinostat (SAHA) | HDAC1 | 5 μM | Axon | 1785 |
Entinostat | HDAC1/3 | 5 μM | Selleck | S1053 |
Panobinostat | HDAC1 | 50Â nM | Selleck | S1030 |
Selisistat | HDAC1 | 50Â nM | Selleck | S1541 |
Chaetocin | KMT1E (SETDB1) | 100Â nM | Sigma | C9492 |
Tazemetostat | KMT6A (EZH2) | 50Â nM | Selleck | S7128 |
Iadademstat (ORY1001) | KDM1A (LSD1) | 50Â nM | Selleck | S7795 |
JMJD2i (Jumonji) | KDM4A (JMJD2A/2E) | 100 µM | Millipore | 420,201 |