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Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Fig. 9

L-TADs are highly mobile within a single cell. Shown are the probabilities of L-TADs to be in contact with the NE. None of the L-TADs stay at the NE all the time, the maximum probability being only 0.85, suggesting a dynamic nature of all LAD–NE contacts. Large red/blue circles are the averages over 6 nuclei with 4 different nucleus topologies (4 CIS and 2 TRANS). Smaller black/green circles are the probabilities for a single CIS-X6S nucleus topology. All nuclei are of 2 \(\mu\)m radius. Statistical error bars are smaller than symbol size. Despite all 350 L-TADs in the model having the same affinity to the NE, there is a significant spread of their probabilities to be near the NE. A non-negligible number of L-TADs, 12%, have a very low (less than 0.2) probability to be at the NE

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Epigenetics & Chromatin

ISSN: 1756-8935