Fig. 7

Probabilities of TADs to be found within 0.4 \(\mu\)m layer adjacent to the NE (half the nuclear volume) for the WT (red) and Lamin mutant (green) model nuclei. Statistical error bars are smaller than symbol size. The WT TADs can be partitioned onto two major groups: the TADs with the probabilities greater than 0.5 and the TADs with the probabilities in the range 0.1\(-\)0.5. The TADs in the second group belong to the sections of chromosomes containing relatively long continuous stretches (10–16 TADs) without LADs. Null L-TADs #15, analyzed in [35] as cytological region 22A, is marked by yellow circles (for the WT and Lamin mutant nuclei). Null L-TADs #120, described in [35] as cytological region 36C, is marked by red triangles. PcG L-TAD #435, analyzed in [35] as cytological region 60D, is marked by blue squares. These three regions have been experimentally shown to detach from the NE in the Lamin mutant nuclei [35]. Our model agrees with the experiment for these three L-TAD regions, providing an additional validation for the model. (Also see model derived cumulative frequencies of radial positions of these regions in Fig. S12 in Additional file 1 for details)