Fig. 3

Top panel: Experimental Hi-C map for TAD–TAD contact probabilities in the WT D. melanogaster embryonic nuclei [26] (original data for embryonic nuclei from Ref. [1]). Bottom panel: Model derived TAD–TAD contact probability (Hi-C) map corresponding to young (0–3 min) nuclei. This Hi-C map reproduces many features expected from experiment: increased interactions within chromosomal arms, long-range chromatin contacts visible as bright spots, genome compartmentalization manifested as plaid-patterns of TAD–TAD contacts, and the Rabl-like configuration represented by interactions between chromosomal arms (e.g. 2 L and 2R) as “wings” stretched perpendicular to the main diagonal. Pearson’s correlation coefficient with the experimental Hi-C map is 0.956