Fig. 2

The temporal evolution of the WT chromatin configurations (top row), and the model derived TAD–TAD contact probability (Hi-C) maps (bottom row). From left to right: The model chromatin configurations at t=0 min (starting configuration), and at time points corresponding to 30 min, 3 h and 11 h. The configurations shown correspond to TRANS-X3S nucleus topology (see Fig. 1), used as an example. The Hi-C maps (bottom row) are each averaged over 5 min (\(3 \cdot 10^6\) time steps) time intervals, and over the ensemble of 18 independent trajectories of the model nucleus, generated with the WT parameter set. The averaging includes all of the starting topologies, see “Methods”