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Fig. 10 | Epigenetics & Chromatin

Fig. 10

From: Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Fig. 10

Examples of qualitatively different predicted radial distributions of several TADs, and their responses to lamin depletion. Top panel: Radial distribution of the PcG L-TAD #435 (cytological region 60D in Ref. [35]) in the WT and Lamin mutant nucleus models. Middle panel: Radial distribution of the Null L-TAD #120 (cytological region 36C in Ref. [35]) in the WT and Lamin mutant model nuclei. Bottom panel: Radial distribution of the Active TAD #22 in the WT and Lamin mutant model nuclei. The distributions of L-TADs (LADs) are bi-modal: the NE-bound mode is characterized by a high and very narrow density peak right at the NE, and the diffusive mode exhibits a noticeable LAD density in the nuclear interior. The bi-modality is consistent with the mobile nature of LADs

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Epigenetics & Chromatin

ISSN: 1756-8935