Fig. 4

snATAC-seq analysis identified distinct nucleus clusters by open chromatin status. A The nuclei were visualized by UMAP and colored by cluster (five mouse and four human clusters). The letters represent the individual samples (or subjects). B UMAPs similar to A but plotted separately for each sample. The numbers indicate the detected nuclei in mouse (top) or human clusters (bottom). C and D Sample-specific read alignment and peak detection at selected genes. C In the gene body of TMEM191B, only reads of the human 1 (female) sample were detected. D In contrast, only reads of the human 2 (male) sample were detected at the promoter region of the human ZFY gene in chromosome Y