Fig. 4

Strong correlations among DNA methylation, gene expression, and body weight in TG epigenome-edited mice at 18.5 dpc. a qRT-PCR analysis of mRNA expression. *P < 0.05, **P < 0.01, ***P < 0.001 (two-tailed Student’s t test). Correlations among b transgene copy number and GFP expression, c H19-DMR methylation (m2 site) and body weight, d H19-DMR methylation (m2 site) and placental weight, e, f H19-DMR methylation (m2 site) and gene expression, and g, h gene expression and body weight, measured by calculating Pearson’s correlation coefficient values (r)