Epigenetics & Chromatin

Table 1 Detectable histone H3 methylation states for the in vitro HMT assays with EHMT1/GLP and EHMT2/G9a

From: De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a

EHMT1/GLP
	Mono-methyl	Di-methyl	Tri-methyl
Lysine 4	X	X	X
Lysine 9	✔	✔	✔
Lysine 14	X	X	X
Lysine 18	✔	✔	✔
Lysine 23	✔	✔	✔
Lysine 27	✔	✔	✔
Lysine 36	X	X	X
EHMT2/G9a
	Mono-methyl	Di-methyl	Tri-methyl
Lysine 4	X	X	X
Lysine 9	✔	✔	✔
Lysine 14	X	X	X
Lysine 18	✔	✔	✔
Lysine 23	✔	✔	X
Lysine 27	✔	✔	✔

The table shows the individual methylation states, detected by western blot and mass spec., for the in vitro HMT reactions with EHMT1/GLP and EHMT2/G9a

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ISSN: 1756-8935

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