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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a

Fig. 3

Pharmacologic inhibition of EHMT1/GLP and EHMT2/G9a decreases H3K9 and H3K23 methylation in vivo. 50B11 (rat) or HEK203 (human) cells were treated with either 10 uM UNC0642 or DMSO for 5 days. At the conclusion of the treatment, the cells were harvested, and extracts were blotted for various histone H3K9 or H3K23 methylation states to evaluate changes in these methylation states in vivo

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Epigenetics & Chromatin

ISSN: 1756-8935