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Table 7 Revised gene nomenclature for human histone H3 genes

From: A standardized nomenclature for mammalian histone genes

Variant symbol

HGNC gene symbol

HGNC gene name

Previous symbol

HGNC ID

UniProt ID

H3.1

H3C1

H3 clustered histone 1

HIST1H3A

HGNC:4766

P68431

H3.1

H3C2

H3 clustered histone 2

HIST1H3B

HGNC:4776

P68431

H3.1

H3C3

H3 clustered histone 3

HIST1H3C

HGNC:4768

P68431

H3.1

H3C4

H3 clustered histone 4

HIST1H3D

HGNC:4767

P68431

NA

H3C5P

H3 clustered histone 5, pseudogene

NA

HGNC:54427

NA

H3.1

H3C6

H3 clustered histone 6

HIST1H3E

HGNC:4769

P68431

H3.1

H3C7

H3 clustered histone 7

HIST1H3F

HGNC:4773

P68431

H3.1

H3C8

H3 clustered histone 8

HIST1H3G

HGNC:4772

P68431

NA

H3C9P

H3 clustered histone 9, pseudogene

HIST1H3PS1

HGNC:18982

NA

H3.1

H3C10

H3 clustered histone 10

HIST1H3H

HGNC:4775

P68431

H3.1

H3C11

H3 clustered histone 11

HIST1H3I

HGNC:4771

P68431

H3.1

H3C12

H3 clustered histone 12

HIST1H3J

HGNC:4774

P68431

H3.2

H3C13

H3 clustered histone 13

HIST2H3D

HGNC:25311

Q71DI3

H3.2

H3C14

H3 clustered histone 14

HIST2H3C

HGNC:20503

Q71DI3

H3.2

H3C15

H3 clustered histone 15

HIST2H3A

HGNC:20505

Q71DI3

H3.3

H3-3A

H3.3 histone A

H3F3, H3F3A

HGNC:4764

P84243

H3.3

H3-3B

H3.3 histone B

H3F3B

HGNC:4765

P84243

H3.4

H3-4

H3.4 histone, cluster member

HIST3H3

HGNC:4778

Q16695

H3.5

H3-5

H3.5 histone

H3F3C

HGNC:33164

Q6NXT2

NA (H3.6)*

H3P16

H3 histone pseudogene 16

H3F3AP6

HGNC:42982

NA

H3.7**

H3-7

H3.7 histone (putative)

HIST2H3PS2

HGNC:32060

Q5TEC6

NA (H3.8)***

H3P44

H3 histone pseudogene 44

H3F3AP5

HGNC:42981

NA

H3.Y.1

H3Y1

H3.Y histone 1

NA

HGNC:43735

P0DPK2

H3.Y.2

H3Y2

H3.Y histone 2

NA

HGNC:43734

P0DPK5

cenH3

CENPA

centromere protein A

NA

HGNC:1851

P49450

  1. *The variant symbol is shown as NA (H3.6) because the encoding gene is annotated as a pseudogene and, therefore, named within the H3 pseudogene series as H3P16, but the variant H3.6 has been reported in the literature
  2. **Although this histone variant has been referred to as H3.7 in the literature, its existence is in doubt and it was not included in the Strasbourg variant nomenclature
  3. ***The variant symbol is shown as NA (H3.8) because, as for H3P16 above, the encoding gene is annotated as a pseudogene, named as H3P44, but the variant H3.8 has been reported in the literature