Table 1 Distributions of maternal and fetal participant and sample characteristics for those with cord blood DNA methylation measures, split by maternal use of prenatal vitamins in month 1 of pregnancy
| Â | MARBLES | EARLI | ||||
|---|---|---|---|---|---|---|
No use of prenatal vitamins month 1 | Use of prenatal vitamins month 1 | P-value | No use of prenatal vitamins month 1 | Use of prenatal vitamins month 1 | P-value | |
N = 99 | N = 102 |  | N = 42 | N = 71 |  | |
Maternal education | ||||||
 No degree | 65 (65.7%) | 37 (36.3%) |  < 0.001 | 24 (57.1%) | 22 (31.0%) | 0.01 |
 College degree | 34 (34.3%) | 65 (63.7%) | 18 (42.9%) | 49 (69.0%) | ||
Maternal age at delivery (years) | 34.8 (4.95) | 34.0 (4.67) | 0.26 | 33.7 (4.48) | 33.1 (4.46) | 0.51 |
Maternal pre-pregnancy BMI | 27.5 (6.92) | 27.9 (6.89) | 0.67 | 27.6 (6.54) | 27.6 (7.89) | 0.98 |
Child race/ethnicity | ||||||
 Non-Hispanic White | 41 (41.4%) | 44 (43.1%) | 0.63 | 22 (52.4%) | 36 (50.7%) | 1.00 |
 Hispanic | 35 (35.4%) | 30 (29.4%) | 5 (11.9%) | 9 (12.7%) | ||
 Other/multiple | 23 (23.2%) | 28 (27.5%) | 15 (35.7%) | 26 (36.6%) | ||
Child sex | ||||||
 Female | 37 (37.4%) | 43 (42.2%) | 0.58 | 25 (59.5%) | 29 (40.8%) | 0.08 |
 Male | 62 (62.6%) | 59 (57.8%) | 17 (40.5%) | 42 (59.2%) | ||
Gestational age at delivery (weeks) | 39.2 (1.15) | 39.1 (1.27) | 0.52 | 39.1 (1.49) | 39.5 (1.33) | 0.24 |
Estimated cell proportion | ||||||
 CD8T | 4.11 (2.89) | 3.66 (2.75) | 0.26 | 3.51 (2.55) | 3.99 (3.00) | 0.37 |
 CD4T | 17.4 (6.08) | 17.8 (5.66) | 0.66 | 17.6 (8.36) | 17.1 (7.31) | 0.74 |
 Natural killer | 3.25 (2.90) | 3.05 (2.73) | 0.62 | 3.39 (2.48) | 3.71 (2.93) | 0.53 |
 B cell | 5.62 (2.88) | 5.36 (2.36) | 0.49 | 5.57 (2.75) | 5.68 (3.10) | 0.84 |
 Monocytes | 10.1 (3.58) | 9.55 (2.58) | 0.20 | 6.92 (3.20) | 7.38 (2.88) | 0.44 |
 Granulocytes | 54.7 (11.8) | 55.3 (9.29) | 0.68 | 56.7 (13.0) | 56.5 (12.0) | 0.95 |
 Nucleated RBC | 5.04 (6.90) | 5.49 (5.88) | 0.62 | 8.02 (6.81) | 6.87 (4.92) | 0.34 |
Mean DNA methylation | ||||||
 Overall | 60.9 (0.91) | 60.9 (0.86) | 0.56 | 51.0 (0.63) | 50.9 (0.98) | 0.23 |
 Open sea | 76.7 (1.15) | 76.6 (1.11) | 0.64 | 74.0 (0.80) | 73.7 (1.33) | 0.17 |
CpG shelf | 78.1 (1.07) | 78.0 (1.01) | 0.69 | 78.4 (0.88) | 78.2 (1.46) | 0.21 |
 CpG shore | 49.6 (0.83) | 49.5 (0.72) | 0.58 | 47.0 (0.65) | 46.8 (0.91) | 0.17 |
 CpG island | 18.0 (0.46) | 17.9 (0.27) | 0.12 | 19.5 (0.53) | 19.4 (0.66) | 0.80 |
DNA methylation laboratory batch1 | ||||||
 1 | 33 (33.3%) | 33 (32.4%) | 0.89 | 38 (90.5%) | 50 (70.4%) | 0.03 |
 2 | 37 (37.4%) | 36 (35.3%) | 4 (9.52%) | 21 (29.6%) | ||
 3 | 29 (29.3%) | 33 (32.4%) |  |  | ||