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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Fig. 5

Properties of methQTLs shared across the tissues and tissue-specific methQTLs. A Distance between the CpG and the SNP, the effect size (slope of the regression) of the methQTL, and the negative common logarithm of the methQTL P-value are visualized. MethQTLs were classified as either shared or tissue-specific. B Enrichment analysis of shared (top) or tissue-specific methQTLs (bottom) in different functional annotations of the genome. Visualized is the common logarithm of the odds ratio and the associated Fisher exact test P-value was computed. P-values below 0.01 are indicated by a bold outline. C LOLA [44] enrichment analysis of the methQTL SNPs for the shared and tissue-specific methQTLs, respectively. ESC embryonic stem cell, AML acute myeloid leukemia

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Epigenetics & Chromatin

ISSN: 1756-8935