Fig. 4
From: Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress
MMS is associated with hyperactivity in the elevated plus (EPM) and open field (OF) maze. (A and B) Representative track plots for control and MMS groups in the EPM, with the open and closed arms of the maze indicated in A. C The MMS group travelled further during the EPM (n = 11/group) (p = 0.02, df = 20), but there were no differences in the time spent in the open (p = 0.457, df = 20), closed (p = 0.267, df = 20) or centre (p = 0.32, df = 20) areas D. E and F Representative track plots for control and MMS groups in the OF with the inner and outer zones indicated in E. G The MMS group travelled further in the OF (n = 11/group) (p = 0.02, df = 21) and spent similar amounts of time in the inner (p = 0.07, df = 20) and outer zones (p = 0.07, df = 20) (H). Independent t-tests were used for C, D, G and H. Error bars indicate standard error of the mean