Table 2 lncRNAs functioning during retinal development

Tug1

Knockdown in neonatal mouse

Malformation or absences of outer segment photoreceptors

[171]

Vax2os

Overexpression in neonatal mouse

Disturb the cell cycle progression in photoreceptor progenitor cells

[128]

Rncr4

Knockdown in mouse embryos and postnatal mice

Control the uniformity of retina layers

[172]

Six3osi

Knockdown and overexpression in neonatal mouse

Upregulation inhibition normal photoreceptors cell specification, knockdown prevented the differentiation of bipolar cell and Müller glial

[173]

RncR2

Knockdown and overexpression in neonatal mouse

Required for amacrine cell, and Müller glia differentiation

[132]

Malat-1

Knockdown postnatal mouse

Might regulate development of retinal neurodegeneration through CREB signaling, retinal microvascular dysfunction

[174, 175]

ZNF503-AS1

Knockdown in hiPSC-RPE

Inhibit RPE differentiation

[135]

Malat-1

Morpholino knockdown zebrafish embryo

Smaller eyes, defective otic capsule

[176]

Megamind

Morpholino knockdown zebrafish embryo

Regulation of eye development

[177]