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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk

Fig. 7

Macrophage images adapted from [26]

A potential mechanism for the development of autoimmune disease risk dependent on early life vitamin D exposure. Decreased VDR binding site methylation in early life increases phenotypic plasticity and susceptibility to vitamin D exposure. Because tissue macrophages persist for months to years, phenotypic settings resulting from vitamin D exposure in early life may lead to a tolerogenic or autoimmune propensity in later life.

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