Fig. 4
From: Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
Characteristics of differentially methylated VDR peaks. a Breakdown of VDR peaks based on differential methylation status and overlap with regions of interest (regulatory regions, CpG islands and island shores; left) and differentially methylated VDR peaks overlapping with regions of interest (right). The majority of regulatory regions demonstrated hypomethylation in cells of paediatric origin. b Overrepresented GO terms (FDR < 0.05) associated with differentially methylated VDR peaks. c Breakdown of differentially methylated myeloid VDR peaks and corresponding annotation overlaps compared with all annotated VDR peaks. d Overlap of currently known non-HLA MS risk genes and their overlap with differentially methylated myeloid VDR peaks (Additional file 5). PTK: protein tyrosine kinase, PI3P: phosphatidylinositol-3-phosphate, CGI: CpG island, PFR: promoter flanking region, TFBS: transcription factor binding site