Fig. 3

ATAC sequencing results of 50% epiboly embryos exposed to PF-06726304 acetate. a Read length distribution of sequences showing a typical ATAC fingerprint. b Violin plot showing log2 read per million (RPM) values of all ATAC peaks (dashed lines indicate median and quartiles). c Enrichment plot showing the global mapping of sequencing reads mapped around the transcriptional start sites (TSSs) of all genes. d Enrichment plot showing the global mapping of sequencing reads mapped over the relative length of all genes. e Density plots of different histone marks and accessible chromatin at dome stage around (upper part) all ATAC peaks and (lower part) differential enriched ATAC peaks located at TSSs spanning a region of 10 kb