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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

Fig. 5

MKK3/P38 signaling axis is epigenetically reinforced through methylation events in critical regulatory regions. a p38 expression (WB) shown between CNFs and PNFs. P38 expression strongly correlates with b promoter methylation in MAPK14 (beta-values shown; p = 0.038; = − 0.6). c, d Phospho-p38 expression and phospho-ERK expression are demonstrated by western blot (c) and were significantly correlated (d) (p = 0.006; = 0.70)

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