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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Chromatin accessibility maps provide evidence of multilineage gene priming in hematopoietic stem cells

Fig. 5

Examples of cis-element priming of lineage-specific genes in HSCs. a GEXC expression data reported expression of Thrombin receptor like 2 (F2lr2) selectively in MkPs. b A cis-element predicted to be associated with F2rl2 by GREAT was accessible in both MkPs and HSCs, but not in any other unipotent cell type. c The F2rl2 CRE contained the transcription factor binding motifs for 9 out of the top 10 enriched motifs in MkPs. The only motif not present is Runx1. d GEXC expression data reported expression of Pyruvate kinase liver and red blood cell (Pklr) in EPs, and not any other cell type. e A cis-element predicted to be associated with Pklr by GREAT was accessible in both EPs and HSCs, but not in any other unipotent cell type. f The Pklr CRE contained the binding motifs for Gata2, Gata4, Gata3 and TRPS1. g GEXC expression data reported selective expression of Mitochondrial tumor suppressor 1 (Mtus1) in GMs and no expression in any other cell type. h A cis-element predicted to be associated with Mtus1 by GREAT was accessible in both GMs and HSCs. i CEBP, CEBP:AP1, HLF, PU.1, NFL3, ETS1, and EHF binding motifs were present in the Mtus1 CRE reported in h. j GEXC expression data reported Interferon regulatory factor 8 (Irf8) expression only in B cells, not in the other unipotent lineage cells or in HSCs. k A cis-element predicted by GREAT to be associated with Irf8 was accessible in both B cells and HSCs. l ZEB1/2, Slug, Ascl2, HEB, and E2A binding motifs were found within the Irf8 CRE displayed in k. m GEXC expression data reported Inducible T cell co-stimulator (Icos) expression only in T cells, but not in the other unipotent lineage cells or HSCs. n A cis-element predicted by GREAT to be associated with Icos was accessible in both T cells and HSCs. o CTCF and WT1 motifs were found within the Icos CRE displayed in n

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