Fig. 7

Intergenic, colocalised peaks of Pf H2A.Z, H3K18ac and H3K27ac compared to other intergenic regions have increased nucleosomal occupancy and increased density of TSSs and are closer to regions of exposed DNA. a Per site normalised P. falciparum MNase-seq read coverage [43] from ring stages (15 h post-invasion) and schizont stages (40 h post-invasion) plotted across all 5567 intergenic regions and across the 2197 ring stage and 2645 schizont stage intergenic, colocalised H2A.Z, H3K18ac and H3K27ac ChIP peaks. Whiskers are minimum and maximum values. Mann Whitney U test ****p < 0.0001. b Average, stranded, P. falciparum TSS tag coverage at 10 and 42 h post-invasion [42] at ICPs and at all other intergenic regions. (Mann–Whitney U test **** p < 0.0001). c Distance between ATACseq peaks [40] in early rings, late rings, trophozoites or schizonts and schizont-stage Pf H2A.Z summits of colocalised, intergenic peaks (ICP) or schizont-stage Pf H2A.Z, intergenic summits that did not colocalise with H3K18ac or H3K27ac peaks (not ICP), t test **** p < 0.0001, ** p < 0.01