Fig. 2

CoP-seq is a robust method for detecting accessible chromatin regions. a The correlation analysis of ATAC-seq, CoP-seq, and FAIRE-seq data by using deeptools. b The browser view of a 212-kb human genomic region showing the peaks of CoP-seq, ATAC-seq, FAIRE-seq, and HiCoP in K562 cells. c Venn diagram of the peaks determined by CoP-seq, ATAC-seq, and FAIRE-seq. It represents the intersected peak numbers from two biological replicates for each method. d Comparison of the peak numbers of ATAC-seq, CoP-seq, and FAIRE-seq in promoters, exons, introns, and other regions. e Summit-centered heatmaps of the ATAC-seq, FAIRE-seq, and CoP-seq peaks in K562 cells. The unique ATAC peaks were the peaks which weren’t detected by FAIRE-seq and CoP-seq, and so on. The FAIRE and ATAC peaks were the peaks which were not detected by CoP-seq, and so on. The common peaks were detected by the three techniques. The data are from two biological replicates of CoP-seq, ATAC-seq, and FAIRE-seq. ATAC-seq and FAIRE-seq data are from SRA database (ATAC-seq: SRR5809235, SRR5809236; FAIRE-seq: SRR402355, SRR402356)