Fig. 7
From: DAMEfinder: a method to detect differential allele-specific methylation
DAMEs overlapping known loci exhibiting loss of imprinting in colorectal cancer. a DAME located in chr14:101,291,540–101,293,480, upstream the imprinted MEG3 gene. The loss of imprinting was significant in both types of CRCs. b DAME located in chr11:2,021,017–2,021,260, upstream the imprinted H19 gene. Loss of imprinting only occurred in CIMP CRCs. c DAME in the GNAS gene located in chr20:57,425,758–57,428,036. Loss of imprinting was detected in both types of CRCs. Y-axis in all panels corresponds to \(\text{ASM}_{\text{tuple}}\) means. Lines connect means at intermediate positions between a pair of CpG sites. Shared areas correspond to confidence intervals at each position (standard errors of the mean)