Fig. 3

Candidate cis-regulatory elements responsible for gene expression changes. a Heat map of normalized coverage based on chromatin accessibility at differentially expressed genes. b Enriched DNA motifs at regions of differentially accessible chromatin that co-locate with differentially expressed genes. c Significantly enriched pathways and motifs based on regions of increased accessibility that are co-located with differentially expressed genes. d Heat map of normalized coverage illustrates co-location of NFYB with regions of increased accessibility in Setd8 mutant erythroblasts. e, f Chromatin accessibility at the Ccng2 and Jun loci demonstrating a peak of increased chromatin accessibility co-located with a region of NFYB occupancy