Fig. 1

Loss of Setd8 alters the chromatin landscape in erythroblasts. a Experimental design of ATAC-seq experiments. Early erythroblasts were sorted from the blood of Setd8 mutant and control embryos, and subjected to tagmentation and sequencing as outlined in [1]. b Overlap of accessible regions in Setd8 mutant and control. c Chromatin accessibility at the Ccng2 and Bak1 loci. Green line highlights regions of chromatin accessibility present in Setd8 mutant but not control. d Significantly enriched pathways based on regions of accessibility exclusively in Setd8 mutant erythroblasts. e Significantly enriched motifs based on regions of accessibility exclusively in Setd8 mutant erythroblasts