Fig. 1

Summary of the cell types and histone modifications analyzed in this project. a Schematic illustration of the cardiovascular system, nine EC types and 33 individual samples (indicated by the prefix “EC”) used in this paper. The yellow and green boxes indicate EC types from the upper body and lower body, respectively. b Workflow to identify the reference sites for ECs. The active promoter and enhancer sites of each sample were identified. For each cell type, the shared sites across all samples were extracted as the reference sites. These were integrated into a single set of reference sites for ECs, which was used for the downstream analyses. ChIA-PET data were utilized to identify the corresponding gene for the reference enhancer sites. c Correlation between observed and expected (from ChIP-seq analysis using linear regression model) gene expression data. Left: example scatterplot of observed and expected gene expression level for genes (data from EC13). Right: Pearson correlation heatmap for representative samples of nine cell types and IMR90 cells (as a negative control)