Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

Table 1 mRNA expression of 10 HOX genes in human anencephaly

Gene	Con (\(\bar{X} \pm S\))	NTDs (\(\bar{X} \pm S\))	t	P value
HOXA4	1.270 ± 0.867	2.835 ± 1.891	− 2.379	0.029
5HOXA5	1.357 ± 0.956	2.887 ± 1.368	− 2.899	0.010
HOXB4	1.234 ± 0.774	2.577 ± 1.463	− 2.567	0.019
HOXB5	1.705 ± 1.069	3.090 ± 1.334	− 2.562	0.020
HOXC4	0.963 ± 0.814	2.311 ± 0.831	− 3.664	0.002
HOXC5	1.174 ± 1.093	1.650 ± 1.459	− 2.561	0.020
HOXD1	2.085 ± 1.175	3.886 ± 1.800	− 2.650	0.016
HOXD3	1.599 ± 1.261	3.190 ± 1.638	− 2.496	0.023
HOXD4	1.759 ± 1.213	3.744 ± 1.781	− 2.913	0.009
HOXD8	1.822 ± 1.191	3.466 ± 1.249	− 3.012	0.007

Data were shown as mean ± SD (n = 10). P < 0.05 means the difference have statistical significance

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