Fig. 7
From: Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects
HOX gene expression was upregulated and H3K27me3 levels were decreased in human anencephaly. a HOX genes were detected with NanoString in the brain tissues from human anencephaly and normal cases. Data are shown as the mean (SD; n = 10). P < 0.05 indicates statistical significance. b Detection of histone H3K27me3 modification in brain tissues from human anencephaly and normal cases by western blotting. Total histone H3 was used as a loading control. Data are shown as the mean (SD; n = 10). c Quantification analysis of the H3K27me3 signal normalized to the H3 signal between human anencephaly and normal cases. d Pearson’s correlation analysis between HOXs expression and H3K27me3 level. P < 0.05 indicates statistical significance