Fig. 3

Methylation DIY. a cg07640666, cg17353896, and cg24324379 are hyper-methylated in IDH1 mutation group in LGG (M value, p value < 0.05). b Major stage plot showing cg10983544 (TRIM58) is much hyper-methylated in stage II lung squamous cell carcinoma (M value, p value = 0.016). c cg04902327 (TRIM58) shows a lower level of methylation with low-level copy number amplification, whereas the other CpGs of TRIM58 show a positive correlation with CNV in lung squamous cell carcinoma (M value, p value < 0.05). − 2: homozygous deletion; − 1: single copy deletion; 0: diploid normal copy; + 1: low-level copy number amplification; + 2: high-level copy number amplification