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Table 1 Comparison of dinucleotide content within primary vs. secondary DMRs (P values)

From: Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences

  CpG GpC ApT TpA ApA+ TpT ApC+ GpT ApG+ CpT CpA+ TpG CpC+ GpG GpA+ TpC
Pat1° vs. Mat1° 0.0240 0.0139 0.0004 0.0444 0.4542 0.2515 0.9681 0.0074 0.0461 0.7065
Pat2° vs. Mat2° 0.4963 0.9369 0.9178 0.9987 0.3756 0.1281 0.2590 0.9287 0.7013 0.6743
Pat1° vs. Pat2° 0.0861 0.0835 0.0102 0.0387 0.2490 0.3482 0.6532 0.0768 0.0486 0.5086
Mat1° vs. Mat2° 0.7422 0.6371 0.7383 0.4821 0.6925 0.1175 0.2031 0.8800 0.9646 0.9638
Pat1° vs. Mat2° 0.1057 0.0472 0.0160 0.0218 0.7908 0.0570 0.2808 0.0187 0.1886 0.7569
Pat2° vs. Mat1° 0.5735 0.7343 0.8067 0.5679 0.4508 0.6926 0.6236 0.9804 0.6192 0.6434
  1. (Pat1° paternally methylated primary DMR, Mat1° maternally methylated primary DMR, Pat2° paternally methylated secondary DMR, Mat2° maternally methylated secondary DMR. Frequency of each dinucleotide was determined as described in “Methods”. P values were calculated using a two-tailed t test for independent samples as described in “Methods”. Raw data are found in Additional file 3