Fig. 6

DNA methylation is distinctly regulated in the soma and germline. a Relative expression of DNMTs. FPKM values of DNMTs were normalized to the highest DNMT within each group. b Kernel density plot of methylation level of single cytosines in the indicated samples, which are methylated to at least 10% in either of the samples. c Boxplots of methylation level of single cytosines in the indicated samples derived from methylated CG sites (mCG > 0.5 in either of the samples). d–f Boxplots of methylation level of single, double, and triple CG containing exons that are methylated to at least 34% and with minimum coverage of 4 reads in at least one of the indicated samples. Lollipops represent CG sites. g–i Proportions of unmethylated (0 ≥ and < 0.1), intermediately methylated (0.1 > and < 0.9), and fully methylated (0.9 > and ≤ 1) exons (same exons as in d–f, respectively). j–l Proportions of single BS-seq reads aligned to the same exons as in d–f, respectively. Black lines represent single reads, red/gray lollipops represent methylated/unmethylated CGs, respectively. m Frequency of highly (mCG ≥ 0.8) and lowly (0.05 < mCG < 0.8) methylated CG sites were averaged in 20-bp bins along methylated genes (averaged genic methylation > 0.05) essentially as described in Fig. 1a