Fig. 7

Direction of change of age-related differentially expressed genes can be predicated based on epigenetic marks in young age. Principle component analysis of epigenetic profiles of upregulated and downregulated genes with aging in the hippocampus (a). Correlation matrix representing the correlations between each principle component with epigenetic marks (b). Box plots comparing highly correlated epigenetic marks with the first principle component in upregulated and downregulated genes with aging (c). Area under the curve of the receive operating characteristic (ROC) curve showing the classification accuracy of differentially expressed to upregulated and downregulated genes for Random Forest model in males (d) and females (e). Feature importance of epigenetic marks for classification accuracy (mean decrease accuracy and mean decrease gini) in males (f) and females (g)