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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

Fig. 3

Genome-wide distribution and dynamics of MeCP2 isoforms. a Bar plot depicting the distributions of regions enriched in the MeCP2 isoforms across eight defined genomic features. b DNA-binding motifs enriched for MeCP2-E1 (and excluding E2) shown as motif logos based on aligned, over-represented patterns found in the binding sites. The overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. c ChIP-seq average profiles across 3 Kb upstream the TSS and 3 Kb downstream the TES of genic regions occupied by E1 at 12 a.m. and 12 p.m. (top) and E2 at 12 a.m. and 12 p.m. (bottom). d Details of the previous representations focusing in a 6 Kb region surrounding the TSS of E1 and E2 bound genes (top and bottom panels, respectively)

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