Fig. 3
Loss of Leo1 leads to repressed transcription of genes located near the telomeres of chromosomes I and II. a The table shows the numbers of differentially regulated genes between leo1∆ and wild-type cells at each time point during quiescence. The R/Bioconductor package EdgeR was used for the analysis of differential gene expression. For a gene to be deemed significant, the FDR adjusted p value had to be less than 0.05. ‘Down’, ‘Not changed’ and ‘Up’ indicate genes downregulated, unchanged and upregulated, respectively, in leo1∆ cells relative to their expression in wild-type cells. Genes were filtered to remove genes with very low or no expression from the analysis. b Genome-wide distribution of regulated genes in leo1∆ cells and wild-type cells. The x-axis indicates the chromosomal positions (× 10−6 bp), and the y-axis shows the log2 fold change (log2FC) values for genes differentially expressed between leo1∆ and wild-type cells. Up- and downregulated genes are shown in blue and red, respectively (FDR < 0.05)